College Football Same Game Picks and Parlay Week 5: USC vs. Colorado Betting on the Buffaloes

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Colorado had a harsh reality check last week when they faced Oregon, resulting in a humbling 42-6 defeat. Despite starting the season with a promising 3-0 record under first-year head coach Deion Sanders, the Buffaloes faced a powerhouse program and struggled. Now, they face another stern test against USC, a team with a perfect 4-0 record, led by reigning Heisman Trophy winner Caleb Williams.

Here’s a Football Same Game Parlay for the USC vs. Colorado matchup, airing at 12:00 pm ET on FOX.

Don’t forget to explore our complete USC vs. Colorado predictions.

Colorado +21.5 (-105)

Shadeur Sanders to score a touchdown (+440)

MarShawn Lloyd Over 88.5 rushing yards (-114)

Parlay odds: +1949

One of the advantages of Same Game Parlays is the ability to correlate plays, and that’s part of the strategy here. Shadeur Sanders scoring a touchdown would be a positive outcome for a Colorado cover. At the same time, plays that aren’t directly correlated can enhance the overall parlay payout. That’s the case with the bet on USC running back MarShawn Lloyd accumulating rushing yards. However, even if Lloyd performs well, there’s no reason why the Buffaloes can’t keep the game within a 21.5-point margin. Let’s delve into each of the three legs.

Colorado +21.5 (-105)

Colorado’s performance against Oregon was eye-opening, but not entirely unexpected. After three season-opening wins, they may have become overconfident, but their level of competition didn’t prepare them to face a powerhouse program, especially on the road. Now, they’ve experienced the challenge of playing against top-tier college football teams, and this time, they have home-field advantage against USC. While Colorado might not win outright, they should put up a more respectable fight. The Buffaloes have shown they thrive when faced with doubt, as they proved by defeating TCU as significant underdogs in the first week of the 2023 season. Meanwhile, USC’s performance in a 42-28 win over Arizona State was underwhelming, with the game remaining a one-possession contest with 8 minutes remaining.

Football Pick: Shadeur Sanders to score a touchdown (+440)

It wouldn’t be surprising to see Shadeur Sanders take matters into his own hands on Saturday. With star receiver Travis Hunter still sidelined, Colorado’s quarterback may not have all his weapons at his disposal. Sanders could also face significant pressure, as USC ranks among the national leaders in sacks after four weeks. Sanders has already scored a rushing touchdown this season and recorded six rushing touchdowns for Jackson State last year before transferring to Colorado.

Football Pick: MarShawn Lloyd Over 88.5 rushing yards (-114)

Lloyd is coming off a stellar 154-yard performance on 14 carries against Arizona State. He has rushed for fewer than 76 yards only once this season. Lloyd now faces a favorable matchup against Colorado, a team that recently allowed a staggering 240 rushing yards to Oregon. The Buffaloes rank among the bottom 10 teams in the country in rushing defense, conceding over 206 yards per game on an average of 5.3 yards per attempt. Even if the home team manages to cover the spread, USC is likely to lead for most of the game, providing Lloyd with numerous opportunities to carry the ball.


This is just my opinion. Please gamble responsibly. Gambling is risky and should only be done with money you can afford to lose.

Please note that odds and availability may change, and it’s important to gamble responsibly. Note: All bets should be made responsibly. The opinions and predictions provided are based on available data and are intended to enhance your understanding and enjoyment of sports betting. The decision to place bets or refrain from betting is solely the responsibility of the bettor. If you experience issues with gambling, please seek assistance.

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