NFL Week 5 Best Bets and Odds: Undefeated Matchups


As we dive headfirst into NFL Week 5, there are only two teams left standing without a loss, and they’re setting the stage for what promises to be an electrifying clash. The undefeated squads in question are the San Francisco 49ers and the Philadelphia Eagles, both of which also squared off in last year’s NFC Championship game. The stakes are high, and the competition is fierce.

NFL Week 5

Our NFL experts have been on fire, delivering impressive results with an 11-2-1 record on sides and an impeccable 5-0 NFL best bets record in Week 4. To keep you ahead of the game, we’ve got the opening lines for Week 5 right here. Be sure to stay tuned for our comprehensive NFL predictions as we unveil our picks for the side and total of every game throughout the week.

NFL Week 5 Opening Lines and Odds

  • Chicago Bears +5.5 (-105) vs. Washington Commanders -5.5 (-110) – Thursday Night Football
  • Jacksonville Jaguars +5.5 (-115) vs. Buffalo Bills -5.5 (-105)
  • Houston Texans +2.5 (-110) vs. Atlanta Falcons -2.5 (-110)
  • Carolina Panthers +8.5 (-105) vs. Detroit Lions -8.5 (-115)
  • Tennessee Titans -1.5 (-102) vs. Indianapolis Colts +1.5 (-120)
  • New York Giants +9.5 (-105) vs. Miami Dolphins -9.5 (-115)
  • Baltimore Ravens -3.5 (-105) vs. Pittsburgh Steelers +3.5 (-115)
  • New Orleans Saints +1.5 (-115) vs. New England Patriots -1.5 (-105)
  • Cincinnati Bengals -5.5 (-105) vs. Arizona Cardinals +5.5 (-115)
  • Philadelphia Eagles -5.5 (-105) vs. Los Angeles Rams +5.5 (-115)
  • Kansas City Chiefs -6 (-110) vs. Minnesota Vikings +6 (-110)
  • New York Jets +2.5 (-105) vs. Denver Broncos -2.5 (-115)
  • Dallas Cowboys +3.5 (-115) vs. San Francisco 49ers -3.5 (-105) – Sunday Night Football
  • Green Bay Packers -1.5 (-104) vs. Las Vegas Raiders +1.5 (-118) – Monday Night Football

Best Early Bet for NFL Week 5: 49ers -3.5 Over Cowboys (-110)

In my humble opinion, the San Francisco 49ers currently reign as the supreme force in football. The Niners kept their pristine record intact with a commanding 35-16 victory over the Cardinals in Week 4. Brock Purdy’s remarkable 20-of-21 completion rate and Christian McCaffrey’s four touchdowns stole the show. While the game may not have been expected to be a nail-biter, it was undeniably impressive to see San Francisco seize an early lead and maintain their dominance.

So far, the 49ers have secured wins by margins of 23, 7, 18, and 19 points across four weeks. They have yet to encounter a worthy adversary, and Week 5 doesn’t appear to be the turning point. Oddsmakers may hold a higher regard for the Cowboys following their Week 4 triumph over the Patriots, but let’s face it, the New England offense isn’t exactly a fearsome juggernaut.

I’d happily back the 49ers up to a touchdown, which makes their 3.5-point spread look like a gift from the football gods. Don’t miss this opportunity to wager on what could be a resounding victory for the 49ers.


This is just my opinion. Please gamble responsibly. Gambling is risky and should only be done with money you can afford to lose.

Please note that odds and availability may change, and it’s important to gamble responsibly. Note: All bets should be made responsibly. The opinions and predictions provided are based on available data and are intended to enhance your understanding and enjoyment of sports betting. The decision to place bets or refrain from betting is solely the responsibility of the bettor. If you experience issues with gambling, please seek assistance.

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Happy betting!

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